Britholites derivatives of apatite’s that contain lanthanium and neodymium in the serial compounds Sr8La2−xNdx(PO4)4(SiO4)2F2 with 0 ≤ x ≤ 2 were subject of the present investigation. The solid state reaction was the route of preparing these materials. Several techniques were employed for the analysis and characterization of the synthesized powders. The chemical analysis results indicated that molar ratio Sr+La+NdP+Si was of about 1.67 value of a stoichiometric powder. The X-ray diffraction data showed single-phase apatites crystallizing in hexagonal structure with P63/m space group were successively obtained. Moreover, the substitution of lanthanium by neodymium in strontium phosphosilicated fluorapatite was total. This was confirmed by the a and c lattice parameters contraction when (x) varies coherently to the sizes of the two cations. The infrared spectroscopy and the 31P NMR (MAS) exhibited the characteristic bands of phosphosilicated fluorapatite. The pressureless sintering of the material achieved a maximum of 89% relative density. The sintered specimens indicated that the Nd content as well as the heating temperature affected the ionic conduction of the materials and the maximum was 1.73 × 10−6 S cm−1 obtained at 1052 K for x = 2.

The past twenty years have witnessed a revolution in biomedical research, with the advent and rapid expansion of cell and molecular biology. These Advances have been applied to the biomaterials field. This paper aims to review the progress in biomaterials and the several therapeutic strategies in order to examine biomaterial interactions at the cellular and the wider host level. The performance of any materials as carriers of different types of drugs, such as antibiotics, as well as growth factors with the express intention of delivering some biologically or pharmacologically active agent is also reviewed. The current status of how protein, cell and gene therapy used to modify the properties of the biomaterial to advance the art of tissue engineering is also updated. Moreover, the favorable properties of nanotechnology exploited in biomedical applications were widely focused on. In our opinion, these advances represent some of the few examples in which the progress of molecular biology has a good chance of early clinical success.

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