In the context of advancements in both heat and mass transfer, the current study intends to analyze the impacts of thermal radiation, Soret, and Dufour on the magnetohydrodynamic boundary layer flow through a vertical spinning cone in porous media. The Dufour effect is the energy flux due to the mass concentration gradient with a reciprocal phenomenon, the Soret effect. Energy expression considers the physical aspects of heat generation and absorption. It is expected that the tangential, circumferential, and normal directions will all have velocity components in flow through a porous media. The governing equations are nonlinear partial differential equations that are rearranged into ordinary differential equations via similarity transformation, and then they are numerically solved using the Runge–Kutta method along with a proper shooting strategy. Graphs are used to examine the impacts of many parameters on flow characteristic velocity, temperature, and concentration, including magnetic parameters, porous parameters, Dufour and Soret parameters, chemical reaction parameters, and more. The numerical findings of the gradient of velocity, the Nusselt and Sherwood numbers, and the surface drag force are tabulated and compared with the current result and the one from the literature. The findings are found to be in good agreement. Circumferential and normal velocities are improved visually for greater values of the porosity parameter, but the tangential velocity behavior of the magnetic parameter exhibits the reverse behavior. In addition, the Dufour parameter and chemical reaction both exhibit diminishing behavior when the Soret parameter increases.