The mechanically synthesized complexes of ciprofloxacin were characterized by physical methods, spectral and biological studies. Spectral studies show that; in the complexes, the ciprofloxacin acted as bidentate ligand which coordinated to the metal ion through the ring carbonyl oxygen and one of the Oxygen atoms of the carboxylate group. Results from microanalysis data shows 1:2 metals to ligand ratio. All the complexes show strong antibacterial activity at all concentrations compared with the free ligand (ciprofloxacin).

New solid-state metal complex of Fe (II) with paracetamol (ligand), that is, [Fe(para)2Cl2] were synthesized mechanically in 1:2 ratio. The complex has been characterized using physicochemical properties and spectral studies. From the IR and electronic spectral studies, the spectra of the complex were different from that of ligand suggesting the formation of coordination compound. Paracetamol was found to be bidentate ligand in which Fe (II) ion coordinated through the oxygen atom of carbonyl of ketone and nitrogen atom of amide in which the complex is assumed to have octahedral geometry. The complex has shown good antimicrobial activities. The solid-state synthetic method is quick and gives a higher yield, without the need of solvent or heating. Its present higher efficiency in terms of materials, time and energy compared to solution-based synthesis. It is therefore, recommended among others that, solid-state synthesis method should be used in the synthesizing drugs with metals.