Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. For several decades, ADPKD was regarded as an adult-onset disease. In the past decade, it has become more widely appreciated that the disease course begins in childhood. However, evidence-based guidelines on how to manage and approach children diagnosed with or at risk of ADPKD are lacking. Also, scoring systems to stratify patients into risk categories have been established only for adults. Overall, there are insufficient data on the clinical course during childhood. We therefore initiated the global ADPedKD project to establish a large international pediatric ADPKD cohort for deep characterization. Methods Global ADPedKD is an international multicenter observational study focusing on childhood-diagnosed ADPKD. This collaborative project is based on interoperable Web-based databases, comprising 7 regional and independent but uniformly organized chapters, namely Africa, Asia, Australia, Europe, North America, South America, and the United Kingdom. In the database, a detailed basic data questionnaire, including genetics, is used in combination with data entry from follow-up visits, to provide both retrospective and prospective longitudinal data on clinical, radiologic, and laboratory findings, as well as therapeutic interventions. Discussion The global ADPedKD initiative aims to characterize in detail the most extensive international pediatric ADPKD cohort reported to date, providing evidence for the development of unified diagnostic, follow-up, and treatment recommendations regarding modifiable disease factors. Moreover, this registry will serve as a platform for the development of clinical and/or biochemical markers predicting the risk of early and progressive disease.

Introduction: Transition from adolescence to adulthood is an important episode in life since it determines a person's long-time health behavior and their tendency to carry chronic diseases. The present study aims to assess oral health behavior and awareness of the young population in Turkey. Methodology: A sample of 2,740 students (1309 male, 1431 female) from 5 different universities studying 10 different degree subjects completed a questionnaire related to their oral health behavior. Age, gender and degree subjects were also recorded. The data were analyzed using SPSS 21.0. Results: 66.6% of the students brushed their teeth twice or more times daily. The brushing frequency of students studying different degree subjects is significantly different(p<0.01). Dental students have the highest brushing frequency whereas sports students have the lowest. 38% of the participants indicated that they use mouthwash; however, only 21.2% used it daily. 21.2% of the participants visit a dentist once or twice per year. 50.9% of the participants experience bleeding while brushing. Only 28.8% had regular scaling and polishing. 22.6% of the participants smoke, while 18.8% stated that they have halitosis. Conclusion: The present study indicated that oral health behavior of young population needs to be further improved. Therefore, oral health education programs should be initiated to emphasize the importance of oral hygiene.