Background ASCO guidelines include incorporation of fertility preservation guidelines into the care of breast oncology patients. The purpose of our study is to examine the baseline knowledge of and preferences concerning fertility preservation among women of childbearing age with newly diagnosed breast cancer at time of initial visit to MSKCC. Methods A questionnaire on reproductive history, fertility knowledge and preservations options was administered to women ages 18-45 years with newly diagnosed breast cancer at MSKCC between May and September 2011. Results Sixty women met the inclusion criteria and were eligible for analysis with a median age of 40 years (range 20–45). We found 50% of women either desired children in the future or were unsure if they wanted children; 9% reported receiving information about fertility preservation options prior to their MSKCC visit. Women who had never been pregnant were more likely than those with prior pregnancies to consider having children in the future (p=0.001), and to contemplate fertility preservation options both before (p=0.001) and after (p=0.0002) cancer treatment. Conclusion Early referral allows patients to take advantage of fertility preservation options while preventing delay in the initiation of systemic therapy. Referral by the breast surgical oncologist at the time of initial visit has the potential to increase fertility knowledge, as it appears many women have not yet received fertility information at this early treatment stage.

Background Periodontal disease is an inflammatory, dysbiotic condition. Studies have shown that in the elderly, periodontal disease was associated with cognitive dysfunction and Alzheimer’s disease. Objective To investigate whether young healthy subjects with periodontal disease have lower cognition compared to those without periodontal disease. The salivary cytokines (IL-1β, TNF-α) levels in relation to cognition were also tested. Methods In a monocenter, cross-sectional study, forty subjects [mean age (SD) = 34 (5) and 48% female] from western Romania were classified into periodontal disease conditions using radiographic assessment: 10 subjects had aggressive periodontitis (AGG_P), 20 chronic mild-moderate periodontitis (CR_P), and 10 no periodontitis (NL_P). Neuropsychological assessment performed by standardized neurologists and psychologist included Rey Auditory Verbal Learning Test (RAVLT), Montreal Cognitive Assessment test (MOCA), Mini-Mental State Examination (MMSE), and Prague tests. Salivary cytokines levels were determined by ELISA. Results RAVLT and MOCA delayed recall scores were lower in AGG_P group compared to NL_P and CR_P. The learning curve was also different with subjects with AGG_P showing reduced learning performance. Contrary to our hypothesis, salivary IL-1β associated with immediate but not delayed cognitive scores. Conclusions These results showed for the first time that subjects with AGG_P had cognitive dysfunction and IL-1β may play a role in this process.

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