Under the Kyosei-4 Project, unprecedented high resolution global and regional climate models were developed on the Earth Simulator to investigate the effect of global warming on tropical cyclones, baiu frontal rainfall systems, and heavy rainfall events that could not be resolved using conventional climate models.For the regional climate model, a nonhydrostatic model (NHM) with a horizontal resolution of 5 km was developed to be used in the simulation of heavy rainfall during the baiu season in Japan. Simulations in June and July were executed for 10 years in present and future global warming climates. It was found that, due to global warming, mean rainfall is projected to increase except in eastern and northern Japan, the frequency of heavy rainfall events would increase and its increment rate become higher for heavier rainfall, and return values for extreme rainfall would grow.Experiments using an NHM with a horizontal resolution of 1 km were conducted to study the effects of resolution. Compared to 5 km resolution, it expresses the organization of rainfall systems causing heavy rainfall and the appearance-frequency distribution of rainfall for variable intensities more realistically.

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Present study was performed to elucidate the clinical features and the treatment of so-called endocrinological polycystic ovarian disease (PCO). 36 cases out of 189 infertile patients who had various ovulatory disturbances were subjected during past four years. They were selected by the definitions as follows; 1) serum LH levels greater than or equal to 30 mIU/ml and serum FSH levels less than or equal to 15 mIU/ml, 2) hyper-response of LH secretion by LH-RH (100 micrograms) loading test; maximum values greater than or equal to 250 mIU/ml. Serum androstenedione (ASD), dehydroepiandrosterone-sulfate (DHA-S), estrone (E1), estradiol (E2), progesterone (P, in the mid-luteal phase) and testosterone (T) levels were examined by RIA method for the purpose of the evaluation of the endocrinological background of the PCO in Japanese women. The same examinations were also done in 8 volunteer women who had normal ovulatory menstrual cycles for the control study. In 6 cases of the PCO patients who showed biphasic BBT charts, the endometrial biopsy was done in the mid-luteal phase at the same time of the blood sampling. And the correlation between various serum hormone levels and the endometrial morphology in the PCO patients was also discussed. Then bromocriptine (5 mg/day) was administered in these patients for more than 30 days and the effect of the treatment was investigated. Serum ASD levels in the PCO patients were significantly higher than those in the control (2.52 +/- 1.30 vs. 1.43 +/- 1.21 ng/ml, M +/- S.D., p less than 0.05), while serum E2 and P levels in the patients were significantly lower than those in the control (E2: 118.6 +/- 39.5 vs. 192.5 +/- 53.9 pg/ml, p less than 0.005. P: 7.26 +/- 5.08 vs. 124.4 +/- 4.6 ng/ml, p less than 0.005, respectively). There were no significant differences in serum levels of the other hormones. By the administration of bromocriptine, serum ASD levels decreased (1.62 +/- 1.34 ng/ml, p less than 0.05), and E2 (177.9 +/- 48.6 pg/ml, p less than 0.025) and P (11.8 +/- 4.3 ng/ml, p less than 0.005) levels increased significantly into the levels of control. Serum LH levels of the patients were also suppressed by the treatment of bromocriptine (42.5 +/- 13.7 vs. 27.4 +/- 12.0 mIU/ml, p less than 0.005), however there was no change in serum FSH levels.(ABSTRACT TRUNCATED AT 400 WORDS)

Present study was performed to investigate whether TRH or metoclopramide (MCP) loading test was useful for the diagnosis of so-called occulted or latent hyperprolactinemia (transient increase of serum prolactin levels more than 30 ng/ml during night; OHP). The circadian profiles of serum prolactin levels were examined in 31 women (age: 23-32 years old) whose BBT charts showed biphasic patterns. Blood samplings had been done every two hours through an intravenous indwelling catheter without any disturbances. And seven cases of the OHP were selected. Five cases of the control were also selected at random. Then, LH-RH (100 micrograms) and TRH (500 micrograms) loading test and LH-RH and MCP (10 mg) loading test were performed to these cases in the mid-luteal phase of the same menstrual cycle at interval of two or three days, and serum FSH, LH and prolactin levels (at 0, 30, 60, 90, 120 min. after the loading test) were determined by radioimmunoassay. Serum prolactin levels in the OHP group showed significant higher levels than those of the control from 22 to 6 o'clock (p less than 0.05-0.005). By the administration of 500 micrograms of TRH, serum prolactin levels of the OHP group increased significantly compared to those of the control at all sampling points (p less than 0.05-0.005), and also by the administration of 10 mg of MCP, the same result was obtained (p less than 0.05-0.02). The maximum peak of serum prolactin levels appeared at 30 min. after TRH or MCP loading.(ABSTRACT TRUNCATED AT 250 WORDS)

A case of delivery after treatment of an ovarian endodermal sinus tumor (stage lc) is reported. The patient was a 27‐year‐old Japanese woman who showed a rapid decrease in α‐fetoprotein after the operation and chemotherapy. Three years later, she became pregnant and bore a female baby without any malformation at full term.