Six hundred thirty cases of non-Hodgkin's lymphoma (NHL) in the Tumour Registry of Manitoba spanning an 11-year period from January 1968 to December 1978 were reviewed. There were 34 cancers from 31 individuals who developed the cancer at least six months after diagnosis of NHL. There was no statistical difference in the incidence of second malignancies in this disease compared with an age-matched population in Manitoba. In particular, no cases of acute leukemia were identified.

One hundred twenty patients about to receive their first treatment with potentially nauseant cancer chemotherapy were randomized to one of six antiemetic treatments: (1) no treatment; (2) placebo; (3) prochlorperazine (PCPZ), 10 mg; (4) Δ9‐tetrahydrocannabinol (THC), 5 mg; (5) THC, 10 mg; (6) THC, 15 mg. Four doses of each medication were given orally at 4‐hour intervals starting 2 hours before chemotherapy. A study nurse was responsible for both objective (nurse) and subjective (patient) symptom questionnaires. Serum levels were obtained at intervals for cross‐reacting cannabinoids. Physiologic measurements including intraocular pressure (IOP), blood pressure, and pulmonary function were also recorded. In summary, the patients were remarkably free of adverse physiologic effects. All intraocular pressures before and after treatment were within the normal range, although a surprising stastistically significant increase in IOP occurred in the group receiving 5 mg THC.