Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and declared as a global pandemic in March 2020. There is a special immune tolerance in pregnant woman, predisposes to a viral infection, then increased risk severe complication. Meta analysis was performed using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidlines with comprehensive literature study was performed in July 2021 through Science Direct, Cochrane, and PubMed, with keywords “COVID-19”, “SARS-CoV-2”, “pregnancy”, “pregnant”, and “complication”, and each parameter we assessed using review manager 5.3. Nine studies with 30,257 infected patients and 1,678,974 non infected patients were included. The data show that preterm birth (odds ratio (OR)=1.43, 95% confidence interval (CI): 1.17-1.74; p=0.0004, inconsistency (I2) =90%) less in non infected groups, no camparable finding in vaginal delivery (OR=0.93, 95% CI: 0.82-1.06; p<0.030, I2=75%) and caesarian delivery (OR=1.07, 95% CI: 0.90-1.28; p<0.045, I2=96%). Intensive care unit (ICU) admission reported high percentage in infected patients (OR=4.87, 95% CI: 3.08-7.71; p<0.0001, I2=93%), we found that obstetric complication in subgroup (OR=1.31, 95% CI: 0.13-1.52; p<0.0003, I2=54%) and mortality (OR=17.41, 95% CI: 11.04-27.46; p<0.0001, I2=0%) less in non infected patients. Pregnancy with infected COVID-19 has high percentage of mortality and morbidity events. Infected and non infected patient has equal chance for vaginal or caesarian delivery.

Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL. Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day. Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels. Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.