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Background. Combined injuries involving brain damage represent the most severe and life-threatening conditions in hemophilia patients. These injuries are characterised by specific situational and behavioural circumstances indicating the presence of victim behaviour in such patients.Aim. To analyse the influence of victim behaviour in hemophilia patients on the formation of combined neurosurgical trauma and the choice of neurosurgical and traumatological treatment approaches.Materials and methods. Twenty five patients (20 patients with hemophilia A and 5 patients with hemophilia B) were included in the study. The patients suffered the following injuries: craniocerebral injuries — 68 (100.0 %); bone fractures — 18 (26.6 %); hematomas of the soft tissues of the face, upper and lower extremities, as well as bruised, lacerated wounds — 50 (73.4 %).Results. The following types of victim behaviour were identified in the hemophilia patients: paranoid — 7 (28.0 %), dependent — 8 (32.0 %), dissociative — 6 (24.0 %) and antisocial — 4 (16.0 %). The patients underwent hemostatic therapy with coagulation factor VIII or IX concentrates and surgical (neurosurgical and/or traumatological) treatment of the injuries associated with victim behaviour. In 51 (75.0 %) cases there was delayed medical care, which was the reason for the complicated course of the post-traumatic period. It was revealed that the best treatment results in patients with severe injuries, including craniocerebral traumas, were achieved in cases where medical assistance was provided in the first three hours after injury. As a result of the treatment, the majority of the patients demonstrated regression of the clinical manifestations of the injury.Conclusions. The proposed tactics for the diagnosis and neurosurgical/traumatological treatment of hemophilia patients with signs of victim behaviour, in whom combined brain injuries are detected, includes a comprehensive assessment of medical history data, clinical and laboratory examination, as well as determination of diagnostic criteria for the choice of patient-specific surgical techniques. It is proposed to use the number of patients’ return visits related to their victim behaviour as a quantitative assessment of the degree of victimization.Conflict of interest: the authors declare no conflict of interest.

The treatment of patients with hematological malignancies is often complicated by a number of negative side effects, which include mental disorders, among which cognitive impairment occupies a special place. Psychopathological, psychological, neuropsychological, neurophysiological and neurovisual methods were used to examine 46 patients with various hematological malignancies during periods prior to allo-HSCT, 1-3 months after allo-HSCT, and 6 months after transplantation. When statistical analysis of data was performed correlation and multivariate analyzes. Patients at each stage of the study identified cognitive impairment caused by a combination of risk factors — the presence of a hematological malignancy, the encephalotropic activity of chemotherapy drugs, and mental, neurological disorders. The characteristic and stable dynamics of CN in the post-transplantation period is traced — a sharp decline in cognitive functions in almost all indicators at once in the early post-transplant period with their gradual recovery by 6 months after allo-HSCT. The attitude of patients to cognitive deficiency also changes during the period of treatment: from anozognosic and hyponozognosic at the pre-transplantation stage to hypernosognostic at long-term periods after allo-HSCT.

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