It is indispensable to maintain a healthy skin from infectious microorganisms like Bacteria, Fungi, viruses and parasites. Most common biological agents Bacteria and Fungi plays a prominent role in worsening the skin infections. Antimicrobial and antifungal studies of various natural ( herbal extracts) and synthetic compounds are still going on to find out the best results against skin infection causing microbes. For the treatment of skin infections: soaps, creams, ointments and skin care lotions containing chemicals are available but due to certain limitations the people are frequently attracted towards herbal formulative products. Cow urine is profound to have a great therapeutic value. Across many parts of the world, cow urine therapy is highly used and recommended by medicinal practioners. Cow urine remove dark circles, black spots and pimples says Gujarat government’s Gauseva and Gauchar Vikas Board. Due to cow urine’s great impact, even branded cosmetic companies started formulating cosmetic commercial products using the cow urine as a constituent in skin care products. Since, numerous researches experimentally proved that cow urine acts as a wide defender of skin.