SUMMARY A method is described which allows the features seen in images generated during computed tomography (CT) of lungs previously removed at necropsy to be compared with those seen in corresponding thin sections made from the same lungs. After removal from the body, lungs were inflation-fixed using warm formalin vapour before being x-rayed and then scanned in the inflated state. Slices corresponding to the CT scan images were made and x-rayed. Paper mounted sections were then prepared from each slice. Using these methods pathological correlative studies can be used both to validate the interpretation of CT scans of lungs and to assess the sensitivity of this imaging technique.Computed tomography (CT) is increasingly used in the investigation of lung disease.-3 Confidence in the interpretation of the images generated can only be acquired by adequate correlative studies. In this hospital three approaches are currently under intensive exploration. Firstly, we are comparing the iesults of CT scanning with the results of lung function tests.4 5 Secondly, we are documenting the appearances of standardised phantoms used to simulate lung structures.6 Thirdly, we are comparing scan images with the detailed structure of both normal and known pathological lesions in lungs removed at necropsy. This paper presents the experience gained by the third approach, which provides information about the validity of interpretation of lung pathology as seen in the images generated by computed tomography of lungs.

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