A series of cholesteryl phenylalkanoic esters was synthesized in which the acyl moiety served as the carrier for radioiodine. Tissue distribution studies in rats revealed that several of these radioiodinated esters selectively accumulated in steroid-secreting tissues, such as the adrenal cortex and ovary. Furthermore, this selective uptake was shown to correlate with the stability of these esters to in vivo hydrolysis. An unexpected finding was the unusually high propensity of some of these esters to localize in the ovary and thus afford a possible approach to ovarian imaging agents.

No abstract