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To assess the value of quantitative analysis of sound touch elastography of tissues around breast lesions to facilitate the evaluation of malignancy of the lesions. MATERIALS AND METHODS: With the permission of the Ethics Committee, every patient signed informed consent forms before the study. One hundred and eighty-two solid breast lesions were analysed retrospectively. Postoperative histopathology proved that 63 lesions were malignant and 119 were benign. All lesions were examined by two-dimensional ultrasonography, colour Doppler ultrasonography and ultrasound elastography including sound touch elastography (STE) and strain elastography. Using pathological diagnosis as the reference, the correlation between each ultrasound marker and the malignancy of the solid breast masses was evaluated by chi-square test, and the logistic regression model was constructed to determine the best diagnostic model with multiple markers. RESULTS: The areas under the receiver operating characteristic (ROC) curve (AUCs) of various elastography markers were compared and the markers with the largest AUC values, including quantitative, semi-quantitative, and distance markers were identified. Logistic regression analysis showed that the combination of accuracy of Breast Imaging Reporting and Data System (BI-RADS) classification þ age þ maximum elasticity value of the tissue around the lesion (EMax_shell) in predicting malignant lesions was higher than that of the other combinations. The prediction model verified that the sensitivity of diagnosis of the mammary lump was 94.12% and the specificity was 84.13%. CONCLUSIONS: EMax_shell in the elasticity is the most valuable marker for the diagnosis of breast cancer, and age combined with EMax_shell can effectively improve the diagnostic efficacy of the BI-RADS classification in breast cancer.

Using 10.1 × 109J/ψ events produced by the Beijing Electron Positron Collider (BEPCII) at a center-of-mass energy $$ \sqrt{s} $$ s = 3.097 GeV and collected with the BESIII detector, we present a search for the rare semi-leptonic decay J/ψ → D−e+νe + c.c. No excess of signal above background is observed, and an upper limit on the branching fraction ℬ(J/ψ → D−e+νe + c. c.) < 7.1 × 10−8 is obtained at 90% confidence level. This is an improvement of more than two orders of magnitude over the previous best limit.

By analyzing 4.48 × 108ψ(3686) events collected with the BESIII detector, we observe the decays χcJ → $$ {nK}_S^0\overline{\Lambda} $$ nK S 0 Λ ¯ + c.c. (J = 0, 1, 2) for the first time, via the radiative transition ψ(3686) → γχcJ. The branching fractions are determined to be (6.65 ± 0.26stat ± 0.41syst) × 10−4, (1.66 ± 0.12stat ± 0.12syst) × 10−4, and (3.58 ± 0.16stat ± 0.23syst) × 10−4 for J = 0, 1, and 2, respectively.