Anatomical illustration has evolved through the centuries, first having artistic and educational purposes and later more strictly medical objectives. Between the eleventh and fifteenth centuries, the analytical model (representation of individual parts, organs and systems) gave way to the composite model (description of the human body as a whole). Between the seventeenth and eighteenth centuries, there was a reversal of tendency: initially the anatomist requested the help of artists, but later the artist asked anatomists to check the accuracy of his work. In this way, anatomical illustration reached a high level of precision. This period also saw the creation of the “La Specola” Zoology Museum's collection of anatomical wax models. Initiated in the eighteenth century, it also included a series of contemporary colour illustrations executed by various artists. Most of the illustrations concern human anatomy, while a small number deal with comparative anatomy. These illustrations, each accompanied by one or more explanatory sheets, were produced to help explain the corresponding wax models. The anatomical wax model collection has been well preserved through the centuries, maintaining its ancient splendour, and it is the object of continuing research and restoration interventions.