Abstract-This paper presents optimization of nano calcium carbonate production parameters to achieve the optimum production rate by using Taguchi method. The combination of optimum level of process parameters was obtained by using the analysis of signal-to-noise (S/N) ratio. The level of importance of the process parameters on production rate was determined by using analysis of variance (ANOVA). It was found that the optimum level of process parameters are solution flow rate of 9 lit/min, gas flow rate of 20 lit/min, and solution concentration of 70 gr/lit within the range of experiments and the process parameters in terms of impact significance were found to be gas flow rate, solution concentration, and solution flow rate, respectively. By using the optimum level of the process parameters, the production rate was enhanced by 168% in comparison to the mean value of the experimental results.Index Terms-Calcium carbonate, nano calcium carbonate, taguchi method, rotation packed bed.