The aim of this article is to show the main aspects of quantitative structure activity relationship (QSAR) modeling for regulatory purposes. We try to answer the question; what makes QSAR models suitable for regulatory uses. The article focuses on directions in QSAR modeling in European Union (EU) and Russia. Difficulties in validation models have been discussed.

Introduction. The world practice of solving environmental problems has shown the effectiveness of modern environmental quality management schemes based on the analysis and risk management. Material and Methods. The use of risk assessment and analysis methodology allows obtaining quantitative characteristics of the possible damage, to compare the potential effects of radiation and chemical factors and to determine priority sources of danger. The main directions of the practical use of results of assessment of the risk arising from the impact of chemicals polluting the environment are: ranking of residential areas according to the levels of health risks from the studied factors, planning and evaluation of the results of social and hygienic monitoring (SHM), including the correction of planning and implementation, taking into account the priority sources of environmental pollution, the priority adjustment of sources of risks posING the greatest threat to public health. Results. Approaches to the research on the comparative assessment of carcinogenic risk and damage to public health from ionizing radiation and chemical carcinogens in various environmental objects have been developed. The results of studies in the locations of nuclear facilities in the Sverdlovsk region, the Kola Peninsula, the Voronezh region, the Krasnoyarsk territory, and the Leningrad region indicate to a much greater impact of the chemical risk factor on the population health compared to the radiation one. The primary environment of health risks in multimedia risk assessment is the air, what should be considered when developing regional environmental policies. Conclusion. The conducted studies have shown Contribution of nuclear power facilities to the formation of man-made risk to public health to be negligible and by orders of magnitude smaller than Contribution of risk from facilities emitting harmful chemicals. Atmospheric air is the main environment for the formation of health risks in the multimedia exposure to chemicals. Therefore, measures aimed at improving the quality of air should be regarded as a priority for the implementation of measures to preserve public health. The obtained results allow detecting the priorities of the policy in the field of health protection and sanitary-epidemiological welfare of the population and contribute to the development of a strategy for further environmentally acceptable socio-economic development of the studied regions.

Risk analysis applied to public health is used to evaluate the ecological safety of the territory of VoronezhOblast, where the Novovoronezh nuclear power plant is located and a new plant is under construction. It is found that for the population of the territory of Voronezh the individual risk of developing cancer because of the contamination of air by chemical carcinogens and the risk of death due to pollutants are 1000-10000 times higher than the risk of developing cancer from the additional irradiation of the population of Novovoronezh associated with the operation of the nuclear power plant. The results obtained showed that modern nuclear technologies have no effect on the public health as compared with sources of chemical risk.Positive worldwide practical experience shows that the most effective measures are adoption of ecologically acceptable technologies and the application of modern schemes for controlling environmental quality which are based on risk analysis and control.A project whose objective was to evaluate the ecological safety of the territory of Voronezh Oblast, where the Novovoronezh nuclear power plant operates and a new plant is under construction, using risk analysis for public health and designating the ecological reference points of its stable development, has been completed at the Institute of Problems in the Safe Development of Nuclear Energy (IBRAE).The following were considered as mandatory conditions for implementing the project: 1) use of risk analysis for public health, adopted in international practice, adapted for the territory of our country and recommend for use by the Federal Service for Consumer Protection and Human Well-being (Rospotrebnadzor);2) participation of the leading Russian specialists in the evaluation and analysis of chemical risks; and 3) participation of specialists from the Rospotrebnadzor office for Voronezh Oblast. The risk analysis methodology is a modern scientific approach to evaluating and controlling technogenic effects. The application of risk analysis to public health makes it possible to quantify the possible harm, compare the consequences

No abstract