The role of human olfactory bulbs remains one of the most interesting questions concerning work of the brain, because this organ is one in which neurogenesis is continuously generated in post-natal and adult periods. Impaired sense of smell is not a pathology that threatens human life, therefore, often remains unnoticed. However, it can directly affect the quality of life, as it leads to malnutrition and certain problems in interpersonal relationships. The study of the functional structure of the olfactory analyzer plays an important role both in clinical and experimental studies, but the question of its features in humans needs detailed research. The material of the research was 18 pairs of the olfactory bulbs of males and females aged from 30 to 90 years that were received at the Poltava Regional Department of Pathology. In order to objectify the data obtained on micropreparations, the following morphometric indices were determined: the specific gravity of the location of cellular elements; the proportion of mitral neurocytes in the entire cell population; percentage ratio of relative quantity between cellular elements, blood microvessels, fibrillar component and homogeneous eosinophilic structures. Correlation analysis of morphometric indices in the general sample revealed the existence of an inverse communication of average strength between the relative number of homogeneous eosinophilic cells and the relative number of cellular elements and blood microvessels, which in turn indicates the etiopathogenetic mechanisms of the formation of these structures. The conducted research makes it possible to conclude that mitral cells as one of the most differentiated in olfactory bulbs are sensitive to the development of hypoxic states; under the conditions of cerebrovascular pathology, the relative amount of the blood vessels of the microvessels decreases, which leads to the disorder of the trophy of the nervous tissue and as a result can lead to neurocytolysis of mitral cells. Changes in the vascular and cellular component indicate a different pathogenesis of changes in human olfactory bulbs in these pathologies and suggest that eosinophilic homogeneous cells are the result of apoptotic neurocytolysis against the background of development of hypoxic states.
The lack of a sufficient amount of anatomical material in Ukrainian medical universities has led to the fact that medical students have to work with the bodies of long-dead people whose condition is of a low educational value. Therefore, animal organs are becoming increasingly important in teaching anatomical disciplines. For example, when studying the eyeball at the department of human anatomy, a bull's eye is used; organs of pigs and rats (larynx, trachea, bronchi, lungs, heart, etc.) are used for the purpose of comparative anatomy. Working with the heart of animals, students can learn to suture wounds of the heart using various surgical techniques, perform mitral commissurotomy. To put various types of liver sutures and to perform on liver resection at practical classes, pork or beef liver can be successfully used. Isolated stomach and intestines are indispensable for developing skills of surgical interventions on the hollow organs of the gastrointestinal tract. When studying a human skeleton, it is very helpful to use mock-ups that were obtained using a 3D printer that arouses the interest of students and increases the effectiveness of practical training. In the absence of anatomical material, medical students use the latest computer technology that allows them to study the human body in three dimensions. However, technical means make it possible to obtain only visual information, ignoring the volumetric and spatial characteristics of the objects under study that is their considerable drawback.
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