This study suggests that long-term dietary protein restriction beneficially reduces albuminuria and renal hemodynamics in IDDM patients with mildly elevated albuminuria. Systemic BP counteracts these effects even in the absence of hypertension. Suboptimal compliance limits diet efficacy.

Renal hemodynamics and sodium excretion were determined before and during infusion of dopamine in doses ranging from 0.25 to 8 μg/kg/min in healthy volunteers (n = 15) and in patients with renal disease and moderately impaired renal function (n = 21, baseline glomerular filtration rate 34–85 ml/min). While in normal volunteers dopamine resulted in marked renal vasodilation (maximal fall in filtration fraction 24%), in patients with moderately impaired renal function, the renal vasodilatory response to dopamine was impaired (maximal fall in FF 13%) and was found to depend on baseline glomerular filtration rate. Infusion of dopamine in doses of 2 μg/kg/min and higher resulted in an increase in urinary sodium excretion, which was comparable for healthy volunteers and patients with renal disease. We conclude that dopamine results in a predominantly efferent glomerular vasodilation and, therefore, may be salutary in lowering intraglomerular hypertension. However, in patients with renal disease the renal hemodynamic response to dopamine infusion is impaired compared to healthy volunteers, while the natriuretic response is maintained.

We prospectively studied renal tubular function during 11 consecutive exacerbations of proliferative glomerulonephritis in 8 patients with systemic lupus erythematosus (SLE). We found a rise in the fractional excretion of β₂-microglobulin (p ≤ 0.05) and dimercaptosuccinic acid (DMSA; p ≤ 0.02) during the exacerbations. These changes coincided with a fall in the glomerular filtration rate (p ≤ 0.02). Since fractional excretion of β₂-micro-globulin and DMSA can be considered as markers for tubular function, their rise during exacerbation and their fall (p ≤ 0.01) to control values during remission indicate that tubular dysfunction frequently occurs during active proliferative glomerulonephritis in SLE and can be influenced by immunosuppressive treatment. As no correlation was found between the different tubular function studies and the activity index of tubulointerstitial abnormalities in the renal biopsy, it is suggested that tubular function studies are probably a more sensitive indicator of tubulointerstitial disease than this activity index.

No abstract

AiBk Australian indigenous biocultural knowledge AmFA Marine and Fisheries Agency, Government of Aceh ceesP Commission on Environmental, Economic and Social Policy ciFor Centre for International Forestry Research ciPs coastal Indigenous peoples FFAlg Caribbean Fisherfolk Action Learning Group FFi Fauna and Flora International FPt Forest-Poverty Toolkit isA interdisciplinary situation analysis mA Millennium Ecosystem Assessment mPA marine protected area nbs nature-based solutions ocr optical character recognition Pen Poverty and Environment Network Pin People in Nature rle Red List of Ecosystems ses social-ecological systems sis Species Information Service slA sustainable livelihoods approach teV total economic value teeB The Economics of the Environment and Biodiversity teks Traditional Entertainment and Kastom Support u potential use (of biodiversity) uc current use (of biodiversity) chapter one PEOPLE IN NATURE box 1.2-Tāne and the three baskets of knowledge Tāne's journey to the heavens is reflected in the following ritual chant and story: This is the journey of sacred footsteps Journeyed about the earth journeyed about the heavens The journey of the ancestral god Tānenuiarangi Who ascended into the heavens to Te Tihi-o-Manono Where he found the parentless source From there he retrieved the baskets of knowledge Te kete-tuauri Te kete-tuatea Te kete-aronui These were distributed and implanted about the earth From which came human life Growing from dim light to full light There was life. Tēnei au te hōkai nei o taku tapuwae Ko te hōkai nuku ko te hōkai rangi Ko te hōkai a tō tupuna a Tānenuiarangi Ka pikitia ai ki te rangi tūhāhā ki te Tihi-o-Manono Ka rokohina atu rā ko Te Matua-kore anake Ka tīkina mai ngā kete o te wānanga Ko te kete-tuauri Ko te kete-tuatea Ko te kete-aronui Ka tiritiria ka poupoua Ka puta mai iho ko te ira tangata Ki te wheiao ki te ao mārama Tihei-mauri ora! PEOPLE IN NATURE Mead, A.T.P. (2016). 'Use of Knowledge Baskets in IUCN' Unpublished paper prepared for IUCN.