HighlightsA large population based analysis to evaluate pathologic response according to time of surgery.LARC patients were treated with modern techniques of radiotherapy and surgery.The rate of pCR increased according to time interval from 12.6% to 31.1%.The pCR increasing was 1.5% (about 0.2%/die) per each week of waiting.Lengthening the interval (>13 weeks) significantly improved the pathological response.

SBRT can be considered as local therapy in patients with lung metastases from CRC.

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IG-SBRT is safe and can be considered as a valid therapy in patients with metastatic prostate cancer requiring a long-lasting metastases control.