Epicondylitis is the most common cause of elbow pain, affecting up to 3,0% of the adult population. A comparative study of platelet-rich plasma (BTP) and betamethasone (diprospan) in the treatment of epicondylitis of the shoulder. 50 patients received injections of betamethasone 2-fold with an interval of 14 days. The main group-50 patients received 2 injections of BTP with an interval of 14 days. The results were evaluated using the psychometric scale Patient-Rated Tennis Elbow Evaluation (PRTEE) after 1, 6 and 12 months. Patients receiving Betamethasone showed the lowest level of pain after 1 month, with a gradual tendency to reduce the clinical effect after 6 months and the increase in clinical symptoms of the disease after 12 months. after treatment. The clinical effect after the use of BTP increases to 6 months with a slight tendency to reduce the effect to 12 months. Our studies have shown a high, up to 86,0% effectiveness of the applied methods of treatment of internal and external epicondylitis of the shoulder using PRP in comparison with glucorticosteroids.