When dogs are invaded with Babesia, metabolic and detoxification processes are disrupted. In this regard, the therapeutic regimen should include drugs that contribute to the normalization of metabolism, and maintenance of liver and kidney function. The purpose of our research was to study the effects of Аminotone on the hematological and biochemical status of dogs during the treatment of babesiosis. For this purpose, Forticarb was administered as an etiological agent to the animals of the control group, and Аminotone was additionally administered to the experimental dogs. Before the experiment and two weeks after the beginning of the treatment, blood was taken from the dogs for hematological and biochemical studies. It was found that the control and experimental animals showed a decrease in leukocytes, ESR, ALT and AST activity, urea, and creatinine and bilirubin concentrations after the recovery. At the same time, an increase in erythrocytes, hematocrit, mean corpuscular volume and hemoglobin was recorded. Аminotone provided more intensive changes in the dogs’ biochemical and hematological status: reduced inflammatory reaction, toxic load on the liver and kidneys, and stimulated hematopoiesis, versus the control. Thus, the drug can be recommended for the combined therapy of canine babesiosis.