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The electronic and magnetic structures of HT-UCo 2 Ge 2 ( high temperature form), UGe 3 and of the new intermetallic system U 3 Co 4 Ge 7 are self-consistently calculated within the local spin density functional theory using the augmented spherical wave (ASW) method. The influence of hybridisation on the chemical bonding and magnetic behaviour is discussed from the densities of states (DOS) as well as from the crystal orbital overlap population (COOP ) which was recently combined with the ASW method. From this we address the modifications of both chemical bonding characteristics and of magnetic polarisations of uranium and cobalt in HT-UCo 2 Ge 2 and UGe 3 , these two compounds being considered as the building blocks of U 3 Co 4 Ge 7 .when we move from the building blocks HT-UCo 2 Ge 2 and

Breast cancer has got much attention in the recent years as it is a one of the complex diseases that can threaten people lives. It can be determined from the levels of secreted proteins in the blood. In this project, we developed a method of finding a threshold to classify the probability of being affected by it in a population based on the levels of the related proteins in relatively small case-control samples. We applied our method to simulated and real data. The results showed that the method we used was accurate in estimating the probability of being diseased in both simulation and real data. Moreover, we were able to calculate the sensitivity and specificity under the null hypothesis of our research question of being diseased or not.