In recent years, bioreactor control is very important due to the challenges associated with the highly non‐linear behaviours. The dynamical structure of the system has been extended compared to previous researches and correspondingly the controller configuration is developed in this approach. This approach deliberates an event‐triggered adaptive fault‐hiding prototype for the non‐linear affine bioreactor system. Since this controller has the ability to hide the faults and external disturbances effects, the separated fault detection, isolation, and identification unit are not required in this approach. Also, the measurement information is triggered by the incidence of a certain event to amend the network resources. The focal advantages of the planned methodology are: (1) Robustness of the planned approach against external disturbances, (2) the presented virtual actuator conceals mechanism faults, (3) the convergence of tracking errors in the presence of both the faults and the external disturbances is guaranteed to neighbourhood of zero, and (4) significantly reducing data exchange based on event‐triggered strategy with a state‐independent threshold. The stability of closed‐loop system is guaranteed based on Lyapunov approach. The simulation results show that the proposed fault‐tolerant approach on the bioreactor systems is effective.

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