This chapter describes soil nutrient management, including fertilizer use in Ghana, then suggests fertilizer use and recommendations. The chapter then discusses fertilizer use integrated with other practices, then diagnose nutrient deficiencies in the region. Further, the chapter provides information on optimizing fertilizer use and fertilizer use optimization tools for Ghana. Finally, the chapter explores how to adjust fertilizer rates for other practices and soil test information, and enumerates targeted crops and cropping systems by agroecological zone.