With the aim of examining proliferative activity of gastric cancers of various histologic types, H3‐thymidine labeling indices of biopsy specimens from 48 patients were examined using an in vitro labeling technique. The results indicated that the indices were greatly variable (1.4–40.8%) from case to case and from area to area, and could not be well correlated with either gross findings, histologic types, or the degree of tumor invasion. However, the distribution of the labeled cells within the tumor was somewhat characteristic to each histologic type. In adenocarcinomas, DNA‐synthesizing cells were scattered at random over the entire tumor tissue. In signet‐ring cell carcinomas, small tumor cells with dark‐staining cytoplasm were preferentially labeled. In contrast, typical signet‐ring cells had practically zero labeling index, suggesting that they are out‐of‐cycle cells and are functionally differentiated.

Two autopsy cases of clear cell variant of hepatocellular carcinoma were reported in which both hypoglycemia and hypercholesterolemia occurred simultaneously. The tumor consisted of lipid-laden clear cells with centrally located nuclei. Glycogen was also stored in the cytoplasm in Case 2 but not in Case 1. In reference to the literature, it was suggested that hypoglycemia and hypercholesterolemia are due to biochemically heterogeneous mechanisms that vary from patient to patient and may involve diversion, hitherto undescribed, of glucose metabolism of tumor tissue in the direction of lipogenesis and/or glycogenesis.

This paper describes a doughnut-like ultrasound (US) finding in pediatric intestinal Burkitt's lymphoma. A 9-year-old boy had a fist-sized, hard, non-movable mass in the lower abdomen. US showed a thickened, layered ring like a doughnut. The outer, low-level echoes seemed to be consistent with mucosa and muscle layers and the inner, high-level echoes seemed to be intraluminal air or mucus. The serum lactic dehydrogenase level was high. At surgery, a solid, hard tumor 15 x 10 cm in size was found in the jejunum. The intestinal wall was diffusely thickened with an intact mucosa. From this experience, the US doughnut sign may be a helpful diagnostic finding in pediatric intestinal Burkitt's lymphoma.

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