We use high-precision photometry of red-giant-branch (RGB) stars in 57 Galactic globular clusters (GCs), mostly from the "Hubble Space Telescope (HST ) UV Legacy Survey of Galactic globular clusters", to identify and characterize their multiple stellar populations. For each cluster the pseudo two-color diagram (or 'chromosome map') is presented, built with a suitable combination of stellar magnitudes in the F275W, F336W, F438W and F814W filters that maximizes the separation between multiple populations. In the chromosome map of most GCs (Type I clusters), stars separate in two distinct groups that we identify with the first (1G) and the second generation (2G). This identification is further supported by noticing that 1G stars have primordial (oxygen-rich, sodium-poor) chemical composition, whereas 2G stars are enhanced in sodium and depleted in oxygen. This 1G-2G separation is not possible for a few GCs where the two sequences have apparently merged into an extended, continuous sequence. In some GCs (Type II clusters) the 1G and/or the 2G sequences appear to be split, hence displaying more complex chromosome maps. These clusters exhibit multiple SGBs also in purely optical color-magnitude diagrams, with the fainter SGB joining into a red RGB which is populated by stars with enhanced heavy-element abundance. We measure the RGB width by using appropriate colors and pseudo-colors. When the metallicity dependence is removed, the RGB width correlates with the cluster mass. The fraction of 1G stars ranges from ∼8% to ∼67% and anticorrelates with the cluster mass, indicating that incidence and complexity of the multiple population phenomenon both increase with cluster mass.

We present abundances of Fe, Na, and O for 1409 red giant stars in 15 galactic globular clusters (GCs), derived from the homogeneous analysis of high-resolution FLAMES/GIRAFFE spectra. Combining the present data with results from our FLAMES/UVES spectra and from previous studies within the project, we obtained a total sample of 1958 stars in 19 clusters, the largest and most homogeneous database of this kind to date. The programme clusters cover a range in metallicity from [Fe/H] = −2.4 dex to [Fe/H] = −0.4 dex, with a wide variety of global parameters (morphology of the horizontal branch, mass, concentration, etc.). For all clusters we find the Na-O anticorrelation, the classical signature of the operation of proton-capture reactions in H-burning at high temperature in a previous generation of more massive stars that are now extinct. Using quantitative criteria (from the morphology and extension of the Na-O anticorrelation), we can define three different components of the stellar population in GCs. We separate a primordial component (P) of first-generation stars, and two components of second-generation stars, that we name intermediate (I) and extreme (E) populations from their different chemical composition. The P component is present in all clusters, and its fraction is almost constant at about one third. The I component represents the bulk of the cluster population. On the other hand, E component is not present in all clusters, and it is more conspicuous in some (but not in all) of the most massive clusters. We discuss the fractions and spatial distributions of these components in our sample and in two additional clusters (M 3 = NGC 5272 and M 13 = NGC6205) with large sets of stars analysed in the literature. We also find that the slope of the anti-correlation (defined by the minimum O and maximum Na abundances) changes from cluster-to-cluster, a change that is represented well by a bilinear relation on cluster metallicity and luminosity. This second dependence suggests a correlation between average mass of polluters and cluster mass.

Osteoporotic structural damage and bone fragility result from reduced bone formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally active drug that dissociates bone remodeling by increasing bone formation and decreasing bone resorption, has been shown to reduce the risk of vertebral fractures and to increase bone mineral density. methods To evaluate the efficacy of strontium ranelate in preventing vertebral fractures in a phase 3 trial, we randomly assigned 1649 postmenopausal women with osteoporosis (low bone mineral density) and at least one vertebral fracture to receive 2 g of oral strontium ranelate per day or placebo for three years. We gave calcium and vitamin D supplements to both groups before and during the study. Vertebral radiographs were obtained annually, and measurements of bone mineral density were performed every six months. results New vertebral fractures occurred in fewer patients in the strontium ranelate group than in the placebo group, with a risk reduction of 49 percent in the first year of treatment and 41 percent during the three-year study period (relative risk, 0.59; 95 percent confidence interval, 0.48 to 0.73). Strontium ranelate increased bone mineral density at month 36 by 14.4 percent at the lumbar spine and 8.3 percent at the femoral neck (P<0.001 for both comparisons). There were no significant differences between the groups in the incidence of serious adverse events. conclusions Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.

Aims. We determine the iron distribution function (IDF) for bulge field stars, in three different fields along the Galactic minor axis and at latitudes b = −4• , b = −6• , and b = −12 • . A fourth field including NGC 6553 is also included in the discussion. Methods. About 800 bulge field K giants were observed with the GIRAFFE spectrograph of FLAMES@VLT at spectral resolution R ∼ 20 000. Several of them were observed again with UVES at R ∼ 45 000 to insure the accuracy of the measurements. The LTE abundance analysis yielded stellar parameters and iron abundances that allowed us to construct an IDF for the bulge that, for the first time, is based on high-resolution spectroscopy for each individual star. Results. The IDF derived here is centered on solar metallicity, and extends from [Fe/H] ∼ −1.5 to [Fe/H] ∼ +0.5. The distribution is asymmetric, with a sharper cutoff on the high-metallicity side, and it is narrower than previously measured. A variation in the mean metallicity along the bulge minor axis is clearly between b = −4• and b = −6 • ([Fe/H] decreasing ∼ by 0.6 dex per kpc). The field at b = −12• is consistent with the presence of a gradient, but its quantification is complicated by the higher disk/bulge fraction in this field. Conclusions. Our findings support a scenario in which both infall and outflow were important during the bulge formation, and then suggest the presence of a radial gradient, which poses some challenges to the scenario in which the bulge would result solely from the vertical heating of the bar.