Novel 1,3,10,3':4,5]pyrimido [6,1-b]quinazolin-8-ones were synthesised by a Niementowski reaction involving condensation of substituted anthranilic acids with a 5,7-disubstituted-3H-pyrido[2,3-d]pyrimidin-4-ones. Microwave irradiation in polyphosphoric acid media was used in order to improve reactions where classical or direct fusion method was limited. The synthesis of title compounds highlights a comparative study of the classical, microwave technique and direct fusion methods.

Starting from 5,6-disubstituted-3H-thieno[2,3-d]pyrimidin-4-ones, novel 1,2,9,11-tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-ones could be reached in two steps through a von Niementowski reaction, which involves condensation of substituted anthranilic acids with a 4-chloro-5,6-disubstituted-3H-thieno[2,3-d]pyrimidines. Microwave irradiation in acetic acid media was used in order to improve reactions where conventional heating was limited

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