This study investigated the mechanisms of superovulation in 4-day cyclic female rats treated with two successive doses of 150 12g/100 g BW FSH in the afternoon of diestrus I and in the

S U M M A R YThin layer-based technology in cervical cancer screening now allows both Papanicolaou staining and HPV testing on the same sample. Here, we show that in situ hybridization with catalyzed reporter deposition is a powerful HPV detection method when applied on thin-layer cervical smears, allowing distinction between two staining patterns suggestive of two different physical states of HPV DNA, where diffuse signals are suggestive of episomes and punctate signals are suggestive of viral DNA integration

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Abstract. Bromocriptine (BRC) was injected on oestrus afternoon at 16.00 h into 5-day cyclic female rats thus causing reduced cycle length to 4-days. When injected on dioestrus 1 at 13.00 h the drug remained without effects. Blood progesterone concentration on dioestrus 1 afternoon and on dioestrus 2 morning was shown to be lower in 5-day cyclic rats given BRC than in their untreated counterparts. No changes in the rate of follicular growth were observed on dioestrus 2 afternoon in BRC injected 5-day cyclic rats. The pattern of prolactin secretion on oestrus afternoon was compared in 4- and 5-day cyclic female rats. High prolactin values were observed on early afternoon in the former and on late afternoon in the latter. The decline in progesterone secretion during the dioestrous period of the cycle was supposed to be responsible for cycle shortening in 5-day cyclic rats given BRC. It was concluded that prolactin might play a critical role in the establishment of a 5-day rhythm in the rat by controlling progesterone secretion during the dioestrous period of the cycle.

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