Objectives:Primary - To measure the prevalence of pain in HIV/AIDS with patients.Secondary - To assess the type, site, severity, management of pain and impact of pain on quality of life in these patients.Design:Multicentre cross-sectional survey (This paper is a pilot study).Settings:ART centre at St. John's Medical College Hospital, Bangalore and Snehadan, A supportive and care centre for HIV/ AIDS patients at Bangalore.Materials and Methods:Data sheet, Brief pain inventory and Short – Form McGill pain questionnaire.Subjects:This is an ongoing study and the pilot study includes 140 HIV/AIDS patients in different stages of the disease.Results:About 66.7% (28/42) in-patients and 24.5% (24/98) out-patients complained of pain. Of the 52 patients who reported pain, 32% (14/52) reported neuropathic pain and 68% (38/52) reported noci-ceptive pain. Headache was most common followed by pain in the soles of feet and low back. Only 26.9% (17/52) received any form of analgesic. Pain severity significantly affects the quality of life.Conclusions:Pain is a common and debilitating symptom of HIV/AIDS. It is however, under-estimated and under treated.