Giurgea, C.E., M.G. Greindl, and S. Preat: Experimental dysnesia induced by 1,4-but not by 1,5benzodiazepines. Drug Dev. Res. S1:023-031, 1982.1,4-benzodiazepines (BDZs) are known to induce mild but consistent dysmnesia in several animal models and in humans, whereas the 1 5 B D Z clobazam is claimed to be devoid of this adverse effect. Systematic animal studies comparing 13-to 1,4-BDZs in this field are lacking. The "threshold" conditioned escape response (t-CER) in the Wistar rat, a recently described learning and memory model, is known to discriminate between 1 3 -and 1,4-BDZs. In this model it has been shown that: all 1 ,4-BDZs studied induce a definite dysmnesia (retention and/or acquisition impairments and, with the exception of diazepam, retrieval impairment); 1 ,4-BDZ dysmnesia is not due to an eventual state-dependency learning; many other psychotropic drugs, in usual doses, do not impair t-CER performances; 1 3 -BDZs (clobazam and triflubazam) do not interfere, even in high doses, with t-CER performance.

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