Methylation of 4-methoxy-1 -/3-D-ribof uranosyl-2pyrimidinone (1) with diazomethane gave 4-methoxy-l -(2-0methyl-/3-D-ribofuranosyl)-2-pyrimidinone (2), 4-methoxy-1-(3-0-methyl-/3-D-ribofuranosyl)-2-pyrimidinone (3), and 4-methoxy-l-(2,3-di-0-methyl-/3-D-ribofuranosyl)-2-pyrimidinone (4). The pure 2'-0-methyl product (2) was isolated in 37 % yield under selected conditions. Acid hydrolysis of 2 gave 2 '-O-methyluridine (5) whereas nucleophilic displacement of the 4-methoxyl function by ammonia or methylamine gave 2 '-0-methylcytidine ( 7) and the new RNA minor component wish to report a general procedure for the synthesis of 2'-0-methyl nucleosides of 4-substituted 2-pyrimidinones. The 3'-0-methyl and 2',3'-di-0-methyl derivatives can also be obtained from the reaction mixture.Numerous reports (see, for example, Smith and Dunn, 1959, Hall, 1964, Tamaoki and Lane, 1968, Lane and Tamaoki 1969, and references therein) have appeared concerning the

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Ring-fluorinated 1,2,4-triazoles have not been previously reported and our interest in 1,2,4-triazoles has prompted us to investigate this class of heterocycles. Conventional synthetic routes to fluoro compounds arc notoriously unreliable when applied to new problems. Consequently, a number of novel methods2 of solvents. Recently the conversion of 3(5)-nitro-1,2,4-triazoles to the corresponding halo derivatives on treatment with halogen acids has been reported.4 The

Synthesis and Pharmacological Study of Antihyperlipaemic Activity of 2-Substituted Thieno(2,3-d)pyrimidin-4(3H)-ones.-Twelve thienopyrimidinones such as (III) are prepared by reaction of the aminothiophene carboxylates (I) with the corresponding nitriles ( II) in the presence of HCl. The chloromethyl derivative (IIIc) is converted into the acetoxymethyl (V) and hydroxymethyl compounds (VI). (IIIc) shows the best antihyperlipaemic activity in various animals. -(SHISHOO, C. J.; DEVANI, M. B.; BHADTI, V. S.; JAIN, K. S.; RATHOD, I. S.; GOYAL, R. K.; GANDHI, T. P.; PATEL, R. B.; NAIK, S. R.; Arzneim.-Forsch. 40 (1990) 5, 567-672; Dep. Pharm. Chem., Lallubhai Motilal Coll. Pharm., Ahmedabad-380009, India; EN)

Eine Reihe von 2,5‐disubstituierten 1,3,4‐Oxadiazolen, z.B. (III), (IV), (V) und (VII), wird synthetisiert.