Physalis minima (PM) belongs to the family Solanaceae. PM has been traditionally used to cure and prevent several disorders as documented in Vedic Texts. Nevertheless, scientific values of traditional claims haven't been explored yet. In the previous study, GCMS analysis of P. minima ethanolic leaf extracts (PMELE) indicated the presence of Cyclobutanol (C4H8O); D-Alanine (C3H7O2N); 2-Heptanol, 6-Amino-2-Methyl (C8H19ON); 1-Pentanol, 4-Amino (C5H13NO); Benzeneethanamine, 3-Fluoro-Beta.,5-Dihydroxy-N-Methyl (C9H12FNO2) and L-Alanine, N-(N-Acetylglycyl)-, Butyl Ester (C11H20N2O4). However, biological activities of these bioactive compounds are not known which hampers the exploitation of these compounds by pharma-industries on a commercial scale. This study on ADMET, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of Bioactive Compounds in PMELE aims to provide baseline information on PBNPs as a potential source of natural lead molecules for next generation drug design, development and therapeutics. Keywords: PM-PBNPs; ADMET; PMELE; Pharmacokinetics; Drug-likeness; Drug Development; Bioactive Compounds