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A major part of the total populace relies upon the conventional plant based medicines. The study was carried out to determine the bioactive compounds in the botanicals viz., Phyllanthus niruri, Emblica officinalis and Psoralea corylifolia through phytochemical screening tests and to estimate the total phenol and flavonoid contents in three botanicals. The results of the phytochemical screening tests indicate the presence of phenols, tannin, flavonoids, saponins, terpenoids, steroids and alkaloids. Phytochemicals from medicinal plants/some botanicals are likely to possess many pharmacological activities such as antioxidant, anti-inflammatory, anti-cancer, antimicrobial effects against various pathogens. The Total Phenol content in Phyllanthus niruri is 115 mg/g and with flavonoid value 70.15 mg/g. The Flavonoid content in Emblica officinalis was found to be 22.52 mg/g. The value varies from plants to plants and the results clearly indicate that plants are rich in various phytochemicals components and it will be more advantage to use these botanicals as natural medicine compared with chemical drugs.