In this research, the cisplatin has been successfully deposited on pure Mg specimen, degradable and promising for the tumor treatment by its local sustained release to prevent the cancer from metastasis and even to achieve its apoptosis. The cathodic polarization tests coupled with electrochemical reactions in various concentrations of cisplatin solutions were qualitatively and quantitatively analyzed to speculate the deposition mechanism of cisplatin by UV visible spectrometer, Fourier transform infrared spectroscopy, field emission scanning electron microscope coupled with energy-dispersive spectroscopy, focused ion beam, and X-ray diffractometer. The drug, cisplatin, is deposited on the pure Mg through exchanging Cl − with OH − , produced by the electrochemical method, to form strong hydrogen bonds for attracting one another. The FESEM images of cisplatin coated Mg specimens reveal that the diameter of cisplatin particle is around 50-150 nm with sphere-like shape. While that on cisplatin/HAp composite is less than 30 nm. Due to the high porosity, the drug loading on cisplatin/HAp coated one can be enhanced from 34.65 to 84.93 μg/cm 2 . Also, the drug release duration can be elongated from one day burst to 3 weeks sustained release, which is promising for future clinical applications. There are many ways to treat cancer, including surgery, chemotherapy, radiotherapy, targeted therapy and so on. Among all these therapeutic methods, the conventional drug administration method, chemotherapy, is an indispensable choice for its high efficiency. Though widely utilized, it causes severe complications. In fact, chemotherapy affects people systemically, which kills not only tumor cells but also normal cells like immune cells. In many situations, people can't help but stop chemotherapy treatment before cancer cells eradicated due to severe side effects including mouth sores, hypersensitivity reactions, nausea, vomiting, diarrhea, low blood counts and hair loss.1 Current development of carriers to release drugs locally at controlled rate, which are more specific and safe due to dramatic reducing the side effects, are interesting and spotlighted.
2-5Over the last 40 years, platinum-based drugs become the significant medicines for cancer therapy, approximately half of cancer patients undergo platinum-based drugs chemotherapeutic treatment. Cisplatin and carboplatin are two major platinum-based drugs used in chemotherapy.5 Cis-diamminedichloroplatinum (II) (CDDP), commonly called cisplatin, is the first anticancer drug, which was discovered in 1965 and approved for clinical use in 1978. 6 It is the preferred medicine for a variety of solid tumors, such as testicular and ovarian cancers, and is also used for treating bladder, cervical, esophageal, and small cell lung cancer. The success in cisplatin-based chemotherapy drugs strongly depends on how careful the drug's dosages are monitored in order to reduce severe side-effects. 5,7 This show how important the localized cancer treatment is through sustaining drug release, ac...
