No abstract

One of the more convenient syntheses of porphobilinogen has been adapted to that of isoporphobilinogen and extended to the lactams of both. Aminomethylation of appropriate 2-free pyrroles by the Tscherniac-Einhorn method gives derivatives of porphobilinogen and isoporphobilinogen. A method for aminomethylating reactive pyrroles is illustrated by the conversion of 2,4-dimethylpyrrole into its 5-N-acetylthiocarboxamide, then into its 5-acetylaminomethyl derivative, using acetyl isothiocyanate then Raney nickel, both at ≤20 °C.

Ausgehend von den 5‐Carboxy‐2‐formyl‐pyrrolen (I) werden durch thermische Decarboxylierung der Oxime, Veresterung der Carboxyalkylgruppen und schließlich Hydrierung an Pd/C Isoporphobilinogen‐ (IIa) und Porphobilinogenmethylesterhydrochlorid (IIb) darge‐ 12A stellt (die angegebenen Ausbb.