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Background:The liver is the major metabolic organ which plays vital role in maintaining glucose homeostasis. Aberrant liver metabolism leads to non-alcoholic fatty liver disease (NAFLD).It adversely builds up insulin resistance, dyslipidaemia, and is probably the most common cause of derangement of liver enzymes and lipid profile in type 2 diabetes mellitus (T2DM).The current study was undertaken to explore the relationship between liver enzymes and lipid profile in pre-diabetes and T2DM. Materials and methods: A total of 618 subjects (203-control, 206-Prediabetes and 209-type 2 diabetes mellitus) were enrolled in this cross-sectional study. Blood pressure and anthropometric indices like height, weight, Body mass index and waist circumference were measured in all subjects. Biochemical parameters like fasting plasma glucose, HbA1c, Lipid profile, liver enzymes-AST, ALT, ALP and GGT were estimated in all the study subjects. Results: In both males and females, the mean levels of BMI, WC, SBP, HbA1c, FPG, GGT, TGL and VLDL showed significant p Value. In Pre-diabetes, both GGT and ALT showed significant positive correlation with TC, TGL, LDL-C and VLDL-C. HDL-C showed negative correlation with ALT. In T2DM, ALT showed significant positive correlation with total cholesterol and LDL-C. GGT showed significant positive correlation with TC, TGL, LDL-C and VLDL-C. Conclusion:By looking at the level of routine blood parameters like Liver enzymes and lipid profile in impaired glycaemia patients, it is possible to assess the extent of liver damage and also the risk of cardiovascular accident .Thereby development of type 2 diabetes mellitus can be prevented at an early stage itself..

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Background and Objective: SARS Cov 2 virus are spreading havoc throughout the world and is responsible for the present pandemic. The clinical presentation of this pandemic has been varied from simple flu like symptoms to severe pneumonia. It is also found to affect multiple organ systems in our body.This study was conducted to find out the variations in the biochemical parameters among SARS Covid patients admitted in our hospital. Materials and Methods: This study was a retrospective cross sectional survey of medical records of 258 SARS Cov 2 patients admitted in Chettinad hospital and research institute from July 2020 to September 2020. Among them 183 were males,75 were females. The details of their liver profile, renal profile, cardiac profile, ferritin levels and LDH levels were retrieved and studied Results: In this study we found a significant difference in the levels of ferritin, LDH, serum albumin, troponin I, CK-MB and BNP levels between patients admitted in ICU and ward. The patients were divided into three groups based on their age as 20-50,50-80 and more than 80 years. We found significant difference in the levels of total protein, serum albumin, ALT, BUN, troponin I and CK –MB values. Regression analysis showed ferritin, LDH and serum albumin to be independent markers in predicting disease severity (p value <0.05). Conclusion: This study has shown that ferritin, LDH and serum albumin are promising biochemical markers in the diagnosis and prognosis of SARS Covid 19 infection.