This research paper provides a viable solution for processing noise affected Electrocardiogram (ECG) signal via digital filter and transmission of ECG signal and reception via cognitive radio (CR) technology. Health assessment signals such as ECG signal, Electroencephalogram (EEG) signal, Electromyogram (EMG) signal are vital for diagnosis and rehabilitation of human welfare among which ECG attains prime importance due to its information on heart functioning. However, electrocardiogram signals are prone to addition of noise such as power line noise 50 Hz mainly due to improper shielding which can lead to wrong interpretation, incorrect diagnosis and at times will eventually lead to loss of human life. On combining signal processing into medical applications misconceptions can be eliminated and diagnosis can be done effectively through a designed digital filter. Effect of noise can be cancelled in an ECG signal and by using cognitive radio technology ECG information can be transmitted to a medical physician mobile terminal for remedial measures relating to medical treatment. Simulation results are shown in matrix laboratory (MATLAB) for cancelling noise in an ECG signal having noise using a digital filter which is designed represented by its transfer function. Also, ECG signal is transmitted and received in a CR system where the metric of probability of error is obtained which can be useful for signal processing fraternity.