Lifestyle, unhealthy eating patterns, and low physical activity become trigger factors of obesity. Therefore, lifestyle modification with an exercise-based nonpharmacological approach is one of the strategies for combat obesity. This study aims to analyse the response of moderate-intensity interval and continuous exercise to irisin level increasing pattern on the obese female. A total of 21 obese females were enrolled in this study and given moderate-intensity interval exercise (MIIE) and moderate-intensity continuous exercise (MICE). ELISA was used to quantify the serum level of irisin in all samples. Statistical analysis was performed using one way-ANOVA and Tukey’s honestly significant difference (HSD) post hoc test. Mean irisin levels of pre-exercise at control (CON), MIIE, and MICE were 3.26±1.28l, 3.44±0.56 and 3.89±1.08 ng/ml, respectively (P=0.519). The mean irisin level of 10 min post-exercise was 2.99±0.86 ng/ml at CON, 4.82±1.01 ng/ml at MIIE, and 5.99±1.27 ng/ml at MICE (P=0.000). The mean irisin levels of 6 h post-exercise were 3.04±0.60, 4.56±0.87, and 5.73±1.02 ng/ml at CON, MIIE, and MICE, respectively (P=0.000). The mean irisin level of 24 h post-exercise was 3.04±0.91 ng/ml at CON, 4.64±0.69 ng/ml at MIIE, and 5.69±1.53 ng/ml at MICE (P=0.002). We conclude that the post-exercise serum irisin level increased in both MICE and MIIE subjects, and the post-exercise serum irisin level maintained higher in the MICE than in the MIIE in the obese female subjects.

The decrease in brain derived neurotrophic factor (BDNF) expression and number of hippocampal neurons are two indicators in the decrease of memory function, cognitive, and learning function. The present study aimed to determine BDNF expression and the number of hippocampal neurons on moderate and high intensity exercise by listening to music. Design of the present study was a randomised control group post-test only design. A total of 33 male rats, Rattus norvegicus strain Wistar, aged eight weeks, with body weight 160±20 g were randomly divided into three groups: Group 1 (G1) (n=11, control group without intervention), Group 2 (G2) (n=11, performed moderate intensity exercise, treadmill 14-16 m/min for 30 min by listening to pop music with fast tempo of 160 beats/min) and Group 3 (G3) (n=11, high intensity exercise, treadmill 22-25 m/min for 20 min by listening to pop music with fast tempo of 160 beats/min). The intervention was performed between 17:00-21:00 pm, three times per week for 12 weeks. Blood and brain samples were obtained and evaluated 12 h after the end of the last exercise. BDNF serum was measured using ELISA and hippocampal neurons were stained by haematoxylin-eosin and counted using OlyVIA software. Study results showed a BDNF for G1 of 1,098.14±135.31 pg/ml, G2 of 1,113.72±65.87 pg/ml, and G3 of 1,331.56±105.35 pg/ml (P=0.001). The total number of hippocampal neurons for G1 was 54.75±6.83 cells, for G2 59.87±7.68 cells, and G3 80.58±9.79 cells (P=0.001). According to the study it can be concluded that high intensity exercise combined by listening to music with a fast tempo of 160 beats/min increases BDNF expression and the number of hippocampal neurons.

A passive lifestyle and lack of exercise are triggering factors in increasing metabolic syndrome, whereas metabolic syndrome is associated with increased morbidity and mortality. This study aimed to analyse an exercise-based non-pharmacological approach combined with instrumental music to the plasma levels of irisin. The study employed a randomised pretest-posttest-only group design recruiting 30 male participants. The individuals aged between 19-21 years, body mass index (BMI) 18.5-24.9 kg/m2, normal blood pressure, normal resting heart rate (RHR), VO2max 40-50 ml/kg bodyweight/min, normal haemoglobin (Hb). The subjects were randomly divided into three groups, MIE (n=10, moderate-intensity exercise), MIEM (n=10, moderate-intensity exercise + instrumental music), and HIE (n=10, high-intensity exercise). Blood sampling was collected from pre- and 5 min post-exercise treatment. ELISA method was used to measure the circulating irisin levels. The non-parametric Kruskal-Wallis test, Mann Whitney test and Spearman correlation were chosen to analyse the data. The results showed that there is no significant difference in pre-exercise irisin levels (ng/ml) in MIE (1.58±0.89), MIEM (1.77±3.12), and HIE (1.65±0.88) with a P-value of 0.098. Importantly, the alteration of irisin levels post-exercise program revealed that the level of this peptide (ng/ml) is higher in HIE (7.28±5.11) compared to MIE (1.95±1.85) and MIEM (4.16±3.40) with a P-value of 0.019. The plasma levels of irisin significantly correlate to energy expenditure (r=0.353, P≤0.01), plasma peroxisome proliferator-activated receptor gamma coactivator-1α (r=0.597, P≤0.001), and high-density lipoprotein (r=0.513, P≤0.01). In summary, increased irisin secretion may directly contribute to the gradual alteration of energy expenditure and correlate to physical exercise intensity-related musical treatment.

Introduction: Diabetes self-care activities is a complex regimen, that required an appropriate tools to asses. The Summary of Diabetes Self-Care Activities (SDSCA) questionnaire is the most widely used tool for assess diabetes self-care activities. The study aimed to testing validity and reliability of the Bahasa Indonesia version of the SDSCA. Methods:  The study applied a forward-backward translation strategy. A pretest and a validation study were conducted. The Bahasa Indonesia version of the SDSCA was reviewed by an expert panel for conceptual and content equivalence to the English version. Furthermore, forty-five and 125 patients with T2DM participated in the pretest and the validation study, respectively. The psychometric properties were evaluated in terms of internal consistency, content validity, concurrent validity, and construct validity. Results:  The content validity index (CVI) and the internal consistency (Cronbach’s alpha) were satisfactory, which are 0.98, and 0.72, respectively. The exploratory factor analysis revealed that SDSCA-I are consistent with the original English version. There are significant correlations between three subscales of SDSCA-I and the diabetes knowledge levels namely general diet (r = 0.274, p = 0.002), physical activity (r = 0.269, p = 0.002), and foot care (r = 0.297, p = 0.001). SDSCA-I was significantly correlated with HbA1c values, in term of general diet (r = -0.205, p = 0.022) and self-monitoring of blood glucose (r = -0.265, p = 0.003). Conclusions:  The translation and psychometric test of the SDSCA-I were satisfactory. The tool could assess the self-care activities of Indonesians with T2DM in all settings.

Diabetes mellitus is a disease characterized by high blood sugar levels due to disruption of the production and function of the hormone insulin. One of the symptoms of diabetes mellitus is a decrease in foot sensitivity which is characterized by a tingling and thick feeling in the feet. This study aims to apply diabetic foot exercise and its effect on the value of the ankle brachial index (ABI) in patients with diabetes mellitus. The research design was a case study on 2 patients with type 2 diabetes mellitus. The instruments used were vascular doppler, jelly, gauze/tissue, sphygmomanometer, bent, and stationery. The intervention by applying diabetes foot exercise 12 steps with a duration of 30 minutes was carried out 3 times a week. The results showed an increase in the ABI value in both patients with an average increase of 0.2. In addition, the patient said that the tingling and thick feeling in the legs decreased. Thus, it is proven that diabetic foot exercise can increase the ABI value in patients with diabetes mellitus. Suggestions for healthcare providers to assess patient knowledge related to diabetic foot exercise, and teach the patient. Foot care is one of the diabetes self-care pillars that can prevent complications and reduce premature death among diabetic patients.Keywords: Ankle Brachial Index;Diabetes Mellitus; Diabetes Foot Exercise AbstrakDiabetes mellitus merupakan penyakit yang ditandai dengan tingginya kadar gula darah akibat terganggunya produksi dan fungsi hormon insulin. Salah satu gejala diabetes mellitus yaitu penurunan sensitivitas kaki yang ditandai dengan rasa kesemutan dan tebal pada kaki. Penelitian ini bertujuan untuk mengaplikasikan senam kaki diabetes dan pengaruhnya terhadap nilai ankle brachial index (ABI) pada pasien diabetes mellitus. Desain penelitian berupa studi kasus pada 2 pasien diabetes mellitus tipe 2. Instrumen yang digunakan berupa doppler vaskuler, jelly, kassa/tissue, sphygmomanometer, bengkok, dan alat tulis. Intervensi dengan mengaplikasikan senam kaki diabetes 12 langkah dengan durasi 30 menit dilakukan selama 3 kali dalam seminggu. Hasil menunjukan terjadi peningkatan nilai ABI pada kedua pasien dengan rata – rata peningkatan 0,2. Selain itu pasien mengatakan rasa kesemutan dan tebal pada kaki sudah berkurang. Dengan demikian, terbukti bahwa senam kaki diabetes dapat meningkatkan nilai ABI pada pasien diabetes mellitus. Saran bagi pelayanan kesehatan untuk mengkaji pengetahuan pasien terkait dengan senam kaki diabetes, dan mengajarkannya. Karena perawatan kaki merupakan salah satu pilar perawatan diabetes mandiri yang dapat mencegah komplikasi dan menurunkan kematian dini akibat diabetes. Kata kunci: Ankle Brachial Index;Diabetes Mellitus; Senam Kaki Diabetes