Manasamitra vatakam (MMV) has long been used as a traditional medicine in India for the treatment of psychosomatic diseases, anxiety neurosis, and stress. The present study was designed to examine the neuroprotective effect of MMV against aluminum (Al)-induced memory impairment and oxidative damage in rats. Neurotoxicity was induced by the administration of Al [100 mg/kg body weight (b.w.) per oral (p.o.)/day] to Wistar albino rats for 90 days. Al administration induced neurotoxicity as well as oxidative stress by affecting the active avoidance and memory impairment, as well as altering antioxidants, such as HSP70 protein, superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and acetylcholinesterase. It was observed that the administration of MMV (100 mg/kg b.w./p.o./day) along with AlCl(3) improves memory performance and antioxidant activity against Al-induced neurotoxicity in rats. In conclusion, these data suggest that MMV can prevent brain damage from Al-induced neurotoxicity in rats and thus can be used as a neuroprotective agent.

Acute abscesses are a surgical emergency and almost always require drainage, especially from supercial sites. This is a study among 100 patients in a tertiary care centre in South India to compare the efcacy of two methods of management of supercial – skin and soft tissue- abscesses in terms of post operative pain, wound healing time, duration of inpatient treatment and recurrence of abscess at primary site. The rst method was the conventional Incision and Open drainage and healing by secondary intention. The second method involved Incision and Drainage and primary closure of the wound with a negative pressure drain. The latter method was found to be signicantly superior to the conventional method in all the above mentioned outcomes. Hence, this method can be promoted along with the use of appropriate antibiotics to lessen the inconveniences of the patients.

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Abstract:Background: Necrotizing soft tissue infections (NSTIs)