N¢ -{[(2-cyano-3-ethyl-3-methyl-3, 4-dihydronaphthalen-1-yl)amino]carbonothionyl}benzamide (II) was synthesized by reaction of 1-amino-3-ethyl-3-methyl-3,4-dihydronaphthalene-2-carbonitrile (aminonitrile I) with benzoylisothiocyanate. Condensation of aminonitrile I with phenylchloroformate yielded carbamate III, which was converted into mono-and disubstituted ureas IV and V via reaction with ammonia and aniline, respectively. A series of 2-substituted condensed triazolobenzoquinazolines (VI -XVI) was synthesized by condensation of carbamate III with hydrazides of aromatic and heteroaromatic carboxylic acids. The antineoplastic and antimonoamineoxidase properties of the synthesized compounds have been studied.

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The interaction of 1-amino-3-methyl-3-ethyl-3,4-dihydronaphthaline-2-carbonitrile (I) with propanoic acid chloranhyride was used to synthesize the corresponding amidonitrile II, which was then cyclized to form 2,5-diethyl-5-methyl-4-oxo-5,6-dihydrobenzo[h]quinazolin-4(3H)-one (III). Interaction of aminonitrile I with triethylorthoformate and carboxylic acid hydrazides yielded 2-substituted 4-methyl-4-ethyl-4,5-dihydrobenzo[h][1,2,4] triazolo[1,5-c]quinazolines (IV-XVIII). The antitumor and anti-monoamine oxidase properties of the compounds obtained were studied.