In the result of the study examined 79 patients, among them 30 patients with isolated course of COPD, stage ІІВ, 22 patients with COPD, stage ІІВ with comorbid CP in exacerbation phase, 27 patients with isolated course of CP. Smoking impacts deprivation of CFTR function, which regulates chlorine ions transport through chorine channel, localized in the epithelial cells of exocrine glands. The inhibition of the functioning of the chloride channel leads to thickening of the exocrine glands secret that results in its poor evacuation and then obstruction with fibrosis in the organs, such as lungs, liver, gallbladder, pancreas. That why tobacco smoking may be a risk factor for development not only COPD, but also CP.

Background Ankylosing spondyloarthritis (AS) is a chronic inflammatory rheumatic disease. Lesion of zygapophysial joints is characterized by more unfavorable course of disease. Objectives To estimate the lesion frequency of the zygapophysial joints by MRI and its impact on vertebral function in patients with AS. Methods The study involved 53 people (males) with AS and disease duration ≤ 10 years. The patients were divided into two groups: Group I – patients without lesion of zygapophysial joint but have syndesmophytis (18 people), Group II – patients with lesion of zygapophysial joint (35 people). All evaluation parameters: 10-point assessment of mobility of the spine in the cervical, thoracic, lumbar parts. Results Zygapophysial joint lesion has a high prevalence at onset disease (61,40%) and precedes, in most cases, by lesions of the vertebral body and ligaments. Involvement of that kind met mostly in patients with peripheral form of the disease: 25 patients (71.42%), especially if the peripheral joints were affected at onset disease. Spinal mobility’s indicants in patients without zygapophysial joint lesions but with the presence of syndesmophyte: neck rotation 1.94 ± 0.70 points, chest excursion 4.32 ± 0.57 cm, lateral flexion 2.88 ± 0.85 points, modified Schober test 5.33 ± 0.83 points. Spinal mobility’s indicants in patients with zygapophysial joint lesions: neck rotation 4.57 ± 0.38 points, chest excursion 2.79 ± 0.27 cm, lateral flexion 5.22 ± 0.41 points, modified Schober test 7.87 ± 0.35 points. We also notified the correlation between the quantity of affected joints and intensity of functional changes in spine mobility. Conclusions We observed the correlation between severity of function changes in the cervical and lumbar spine, chest excursion and the presence of facets joints lesions. The differences between groups with and without facet joint lesions were statisticaly significant, that indicates more unfavourable prognosis for a clinical course. Disclosure of Interest None Declared

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Background Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. Magnetic resonance imaging (MRI) is currently used not only to facilitate early diagnosis of the AS, but also to monitor the course of inflammation. Objectives To evaluate the differences in clinical and functional impairment for different duration of the disease in AS patients with and without of active inflammation on MRI. Methods Study involved 40 people (males) with AS and disease duration <10 years and >10 years. The patients were divided into two groups: Group I – patients without inflammation on MRI or with postinflammatory changes (20 people), Group II – patients with inflammation on MRI (20 people). All evaluation parameters: 10-point assessment of mobility of the spine in the cervical (neck rotation), thoracic (lateral flexion), lumbar parts (modified Schober test), indexes BASMI, BASDAI. All patients underwent MRI of sacroiliac joints and the spine. Results Between groups 1 (without inflammation on MRI) and 2 (with inflammation on MRI) were obtained following differences: index BASDAI: <10 years disease duration: 4,10±1,0 vs 4,03±0,48; >10 years of disease duration: 2,36±0,40 vs 3,92±0,35 (p<0,05). Mobility in the cervical parts of spine: <10 years disease duration: 2,75±0,47 vs 5,22±0,52 (p<0,05); >10 years disease duration: 7,49±0,46 vs 7,40±0,35. Mobility in the thoracic parts of spine: <10 years disease duration: 3,50±0,28 vs 6,22±0,72 (p<0,05); >10 years disease duration: 8,50±0,39 vs 8,60±0,65. Mobility in the lumbar parts of spine: <10 years disease duration: 5,75±0,25 vs 8,55±0,50 (p<0,05); >10 years disease duration: 9,81±0,34 vs 9,40±0,55. Index BASMI: <10 years disease duration: 2,60±0,41 vs 4,38±0,38 (p<0,05); >10 years disease duration: 6,06±0,25 vs 5,92±0,41. Conclusions In patients with active inflammation on MRI mobility impairments were significantly higher in all parts of the spine in the early stages of the disease (up to 10 years AS duration), and disease activity was significantly higher than in patients without osteitis at disease duration over 10 years. This indicates a lower quality of life for patients with active inflammation on MRI as on the early so on the late stages of the disease. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2663

The article presents the current literature data concerning the mechanisms of influence of persistent inflammation in chronic obstructive pulmonary disease on the state of the mucous barrier of bronchi and intestines. We consider a variety of factors that get activated during inflammation and adversely affect the progression of changes in mucosal barrier. It is shown that the progression of disorders in bronchial mucosal barrier occurs by developing peribronchial fibrosis and activation of connective tissue with the formation of irreversible airflow obstruction and remodeling of the bronchial tree. Integral interrelations of many stimuli, including growth factors and matrix-generating signals that are involved in inflammation, repair and fibrosis launch epithelial-mesenchymal transformation (EMT), which may lead to loss of epithelial cells and contribute to the destruction of the parenchyma and fibrosis. Detection of EMT in biopsy samples may be diagnostically significant and represent a new biomarker of progression of chronic lung disease.