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The study explores the effect of lipopolysaccharides of various composition from Gramnegative bacteria on phagocytic activity and oxygen-dependent metabolism of macrophages, intensity of lipid peroxidation, and activity of microsomal enzymes in mouse liver, and production of interleukin-1 and tumor necrosis factor by cultured peripheral blood mononuclears. It is found that the magnitude of inhibiting effect of lipopolysaccharides on microsomal oxidation is a mirror reflection of the degree of their prooxidant effect and activation of phagocytic and secretory macrophage functions, which confirms tight coupling of these processes under conditions of acute phase response. Key Words: bacterial lipopolysaccharides; microsomal oxidation; macrophage activityIt has been found that administration of various immunostimulators and the development of viral and bacterial infections are accompanied by suppression of cytochrome P-450-dependent liver monooxygenases in hepatic and other tissues. This effect is related to maerophage activation and is mediated by interferon and early cytokines such as interleukin-1, interleukin-6, tumor necrosis factor (TNF) etc., which inhibit the cytochrome P-450 gene expression [4,13,14]. Inhibition of microsomal oxygenases is probably required for glucoeortieoid biotransformation under conditions of acute phase reaction and in cooperation with other factors promotes restoration of homeostasis in immune stress [5].On the other hand, generation of reactive oxygen species, oxidized halogenides, and nitric oxide by macrophages, activation of lipid peroxidation (LPO),

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