Aims: To assess the prevalence and cumulative incidence of open angle glaucoma (OAG) in a cohort group of siblings of OAG probands. Methods: Between 1994 and 2003, a group of siblings of OAG probands underwent both initial and follow up standardised ophthalmic examinations. Siblings were classified as ''definite glaucoma'' (primary OAG (POAG) and normal tension glaucoma (NTG)), ''glaucoma suspects'' (NTG suspects or ocular hypertension (OHT)), and normal. The prevalence and cumulative incidence of OAG over the follow up interval were calculated. Results: At the initial study, 271 siblings (mean age 63.6 years; female to male ratio 1.2) from 156 probands were examined. 32 (11.8%) were classified as definite glaucoma and 15 (5.5%) as suspects. In the follow up study, 157 of the 224 ''normal'' siblings from the initial study were examined (mean interval from initial study 7.0 (SD 1.0) years). 11 (7%) were classified as definite glaucoma and 30 (19.1%) as suspects. There were significant trends of increasing prevalence and incidence of OAG with age and a lifetime risk estimated at approximately 20% by age 70. Conclusion: Siblings of glaucoma patients have an increased risk of developing glaucoma and the risk increases with age. An effective and repeated screening programme should be considered for this high risk group.

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In a prospective study all contact lens wearers presenting to the ophthalmic casualty department of the University Hospital Nottingham within a six month period were examined to determine the number and pattern of ophthalmic problems occurring in this group. This information was then compared with prescribing information from contact lens dispensers in the city. The incidence of problems associated with contact lens wear within the first six months of starting to use a new contact lens was found to be 0.9% for soft daily wear lenses and 0.8% for rigid lenses. Reservations about these figures are discussed. The similarity between the incidence for the two types of lenses appears to contradict previous suggestions that soft lens wearers are more at risk of developing complications. It may be that the early period of lens wear represents a favoured time with respect to soft lens induced disease while hard lens problems are more common at this time. Both giant papillary conjunctivitis and corneal ulceration were seen in significant numbers but neither were associated with one particular lens type.

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