In the present work, nanocrystalline hydroxyapatite/alumina (HAp−Al 2 O 3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp−Al 2 O 3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp−Al 2 O 3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 μg ml −1. These studies facilitate the formation of biocompatible HAp−Al 2 O 3 composite nanorods for biomedical applications.

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