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Autism Spectrum Disorder (ASD) is a neuro developmental disorder in DSM-5, characterized by social deficits and communication difficulties, stereotyped or repetitive behaviours and interests, sensory issues, and in some cases, cognitive delays. Prevalence of ASD is ever increasing recently throughout the world. There aren’t enough studies which have considered the qualities of life (QoL) of Autistic children through there are many comparing the QoL of parents of children with ASD. Hence there is need for more research on the quality of life of autistic children. The diagnostic criteria for ASD are available in the revised text edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) of the American Psychiatric Association. This study assesses the Paediatric Quality of Life (PQOL) of ASD children, from a multidimensional perspective based on the Cross-sectional survey which considered Physiological function, emotional function, social function and school performance. This study aimed to evaluate the QoL of children with ASD aged 2–12 years. 98 autistic children (male: 69, female: 29; 2- 4 years old: 40, 5- 7 year old: 43, 8 - 12 years old: 15) and 100 normal children (control group) are brought into this study. The children satisfying the DSM-5 as ASD were subjected to assessment of their QoL with Pediatric Quality of Life Inventory (PedsQL)  questionnaire by their parents, compared with standard scores. Present study shows lower scores in the test group on the PedsQL4.0 universality Core scale in comparison with the control group. Behaviour issues had a negative effect on Community adaptation, mental health, a lower intelligence-related quality of life for children and clinically significant autistic symptoms in comparison with children with fewer symptoms. Results suggest greater impairment in adaptive functioning and emotional disorders. For mild-moderate ASD children, better development probably played a significant role in response to rehabilitation, to achieve and maintain the best level of overall outcome. The severity of the disorder and coping strategies in social settings were related to self-care ability and adaptation and intelligence. Hence pediatricians are must evaluate these children for early interventions and medications, if needed, and have QoL integrated in the overall care plan.