The present study prospectively assessed pregnancy outcome of women taking probiotics during the periconceptional period. A group of 104 women who had taken Lactobacillus in early pregnancy and 200 age- and parity-matched control pregnant women exposed to non-teratogenic agents were also recruited into the study and followed-up prospectively. Median gestational age of women exposed to Lactobacillus was 5.2 (range: 1.9-17.6) weeks. Exposure was at a mean dose of 510 mg/day for a median of 4.0 days (range: 1-90 days). In the exposed group, pregnancy outcomes included 96 live births and eight spontaneous abortions versus 187 live births and 21 spontaneous abortions in the non-exposed group. There was no statistical difference in adverse pregnancy outcomes, including the number of spontaneous abortions, pre-term births as well as a low birth weight between the two groups (p > 0.05). In the exposed group, there were two (2.1%) major congenital malformations in comparison with five (2.7%) in the comparison group (p = 0.7). In conclusion, no association was identified between ingestion of Lactobacillus in early pregnancy for a limited period of time and adverse pregnancy outcomes. However, rare pregnancy outcomes may have been missed due to the limited sample size included in the study.

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Oral poster abstracts to a Down baby. One patient did not have any invasive procedure following positive screening and had IUFD of a Down fetus occurred at 36 weeks. We did not observe any spontaneous fetal loss in all the other cases. Conclusions: Our data do not support the hypothesis that first trimester screening is likely to detect a large proportion of affected foetuses that would die spontaneously in utero. Although TOPs were performed early in pregnancy in our population, those cases with late diagnosis or TOP did not lead to spontaneous fetal loss in the interval. OP01.12 Karyotype and outcome of fetuses with increased nuchal translucency above 99 th percentile