* BACKGROUND AND OBJECTIVE: To determine whether adjunctive use of mitomycin C (MMC) would increase the success rate of primary nonpenetrating deep sclerectomy with collagen implant. * PATIENTS AND METHODS: Twenty-six patients (26 eyes) with primary open-angle glaucoma uncontrolled with maximally tolerated medical therapy were randomly assigned to undergo nonpenetrating deep sclerectomy and collagen implant, either with (13 eyes) or without (13 eyes) 0.3 mg/mL of adjunctive MMC for 3 minutes. Intraocular pressure (IOP), number of glaucoma medications, and visual acuity were assessed before and 12 and 24 months after surgery. * RESULTS: The mean age of the study patients was similar in both groups (MMC = 68.1 ± 8 years, control = 65.8 ± 6.8 years). At the 12- and 24-month follow-up visits, the mean IOP with or without medications was lower in the MMC group than in the control group (15.6 ± 3.5 vs 17.2 ± 3.9 mm Hg at 12 months and 15.8 ± 5.6 vs 17.8 ± 2.8 mm Hg at 24 months, respectively). The IOP with or without medications significandy decreased after surgery in both groups (P < .05). Twelve months after surgery, the IOP decreased by 48% in the MMC group and by 35% in the control group. At the end of follow-up (24 months), the IOP decreased by 48% in the MMC group and by 32% in the control group (P= .01). The mean number of glaucoma medications decreased after surgery, there was no significant difference in complications (hyphema and suprachoroidal hemorrhage), and visual acuity was unchanged throughout the study in both groups. * CONCLUSION: The use of MMC in nonpenetrating deep sclerectomy with collagen implant is safe and improves surgical results. [Ophthalmic Surg Lasers Imaging 2004;35:6-12.]

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Glaucoma is a socially significant disease and ranks first among the causes of visual impairment and blindness. Glaucoma is a chronic disease with progressive course, and the entire treatment and diagnostic process is associated with the need for constant monitoring of the structural and functional components of the visual system to assess the progression of glaucomatous optic neuropathy. With adequately chosen treatment tactics, it is possible to stabilize the glaucomatous process and successfully reverse the structural and functional changes thanks to the links between functional defects of the visual fields and topographic damage in the optic nerve with the stage of the disease. This statement emphasizes the need to choose the correct treatment tactics, as well as to closely monitor the structural and functional characteristics of patients with glaucoma. In this regard, the issue of studying the safety and effectiveness of various glaucoma surgeries depending on observation time remains relevant.

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Purpose. To reveal the features of diagnosis and treatment of glaucoma in a group of young patients. Material and methods. Complex ophthalmological examination of 10 young patients diagnosed with glaucoma. Among them, three are on conservative treatment, the rest underwent non-penetrating deep sclerectomy with Xenoplast drainage implantation. Results. Patients who have undergone surgical treatment, especially in the early stages of glaucoma, are able to stabilize the pathological process, while maintaining visual functions at a high level. In an unoperated patient with myopia and nNDST, on maximum antihypertensive therapy, a negative trend was noted according to OCT. In the only case, a patient with emmetropia has stable indicators for several years on drug treatment (prostaglandin analogues). Conclusion. Timely diagnosis and implementation of nonpenetrating deep sclerectomy in the early stages are the main links in the successful treatment of young glaucoma. Patients with axial myopia and glaucoma should be evaluated cardiologically and orthopedically for signs of connective tissue damage. Undifferentiated connective tissue dysplasia may be the pathophysiological basis of the glaucoma process. Key words: glaucoma of a young age, inherited disorders of connective tissue, juvenile glaucoma