Experimental studies of diethyl adipate saponification in a CSTR show that forced cycling of feed composition produces significant yield increases in intermediate product relative to the optimal steady state operation, while forced temperature cycling has much less effect. Related experiments provide useful transient heat transfer data for this system. Reaction kinetics have been determined in water and in a 5070 (v/v) isopropanol solvent.onsecutive-competitive reactions are of great in-

A mathematical model has been employed to examine the interplay of reaction and mass transfer in immobilized enzyme systems involving reaction-generated enzyme poisions. Deactivation rates can be significantly reduced in some cases by catalyzing a purification reaction in which the poison is transformed into an innocuous substance. This conclusion in illustrated experimentally for reaction-generated H2O2 in a continuous-flow stirred slurry reactor containing glucose oxidase immobilized on activated carbon.

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