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in IE rotation (r2¼0.33) and total reaction moments (r2¼0.66). There were no differences in walking speed or step-length for any treatment. Conclusion: The shift towards greater tibia internal rotation and the association with external joint moments suggests that with treatment of Celecoxib there may be a lessening of bracing or co-contraction around the joint that results from pain and inflammation. A rotational shift in joint kinematics has previously been linked with patterns of cartilage thinning. The different kinematic response between the two treatment arms suggest potential differences in the impact of these drugs on ambulation and may have implications for different rates of disease progression that require further study.

Background of the study: Leprosy is a wide spread infectious disease caused by mycobacterium leprae & usually starts as a patch on the skin, but it can also affect & damage the nerves leading to secondary impairments in the face, hands and feet. Plantar ulceration is one of the common impairment occurring in subjects of leprosy, which punched out ulcer surrounded by thickened skin due to direct pressure, shearing force, direct injury, heat. It may occur as sinuses or as shallow ulcers involving the tissues at various level and usually heal with good wound care and dressings, but takes longer time.Objective of the study: To evaluate and compare the improvement of healing of plantar ulcer during 4week intervention period in leprosy subjects treated with active resisted exercise vs subjects treated conventionally. Methods Design: Quasi randomised trial.Study settings: The central leprosum, govt hospital, magadi road, bengaluru. Sample size: 26 Outcome measures: Wound area measurement in mm 2 on a graph paper. Results:The mean value of ulcer area at baseline for group A was 1038.15(599.77) mm 2 & group B was 997.07(804.47) mm 2 and at day 30 the value for group A is 318(311.65) mm 2 & for group B is 720.84(673.19) mm 2 . This study showed a significant improvement in reduction of ulcer area in both the groups. Group A demonstrated significantly better improvements than Group B. Conclusion: Active resisted exercise showed a significant improvement in healing of planter ulcer of leprosy subjects compared to control group.