Rapid useful and easy spectrophotometric method for quantitative analysis of Gliclazide(GLZ)in raw material and tablets pharmaceutical formulation has been described. This method is based on the formation of yellow ion-pair complex between (GLZ) and Bromocresol purple (BCP) in Toluene medium. Different parameters affecting the reaction such as: effect of solvents, time, reagent concentration, correlation ratio, etc. were optimized. The absorbance of the formed complex GLZ-BCP was measured by visible spectrum at absorption maximum 415 nm. The range of linearity was(4.85 – 113.19) µg/mL,regression analysis had a good correlation coefficient R2 = 0.9999. The limit of detection (LOD)and limit of quantification (LOQ)were to be 0.47µg/mL and 1.44µg/mL respectively. The average percent recovery of (GLZ) was found to be (99.73 – 100.41)%. The method was successfully applied for the determination of (GLZ) in tablets pharmaceutical formulations in Syrian pharmaceutical products: UNICRON. The proposed method is simple, direct, and sensitiveand does not require any pre-extractionprocess. Thus, the method could be ready to apply in routine analysis and quality control.

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